Monday, March 5, 2012

Tamoxifen increases adenocarcinoma cell growth, shifts ERalpha/ERbeta ratio.

2004 OCT 11 - (NewsRx.com & NewsRx.net) -- A comparison of tamoxifen's and raloxifene's effects on estrogen receptor expression found that the former increases adenocarcinoma cell proliferation and alters the ERalpha/ERbeta ratio

"Tamoxifen and raloxifene are widely used in clinical practice. It has been found that tamoxifen treatment increases the risk of development of endometrial cancer. The effects of tamoxifen and raloxifene on endometrium might be caused by different estrogen receptor expression," hypothesized M. Koda and colleagues at the Medical University of Bialystok, Poland.

These researchers used immunohistochemical techniques to study "the …

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